Computational investigation of multivalent binding of a ligand coated particle: Role of shape, size and ligand heterogeneity from a free energy landscape perspective
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We present a simple yet accurate numerical approach to compute the free energy of binding of multivalent objects on a receptor-coated surface. The method correctly accounts for the fact that one ligand can bind to at most one receptor. The numerical approach is based on a saddle-point approximation to the computation of a complex residue. We compare our theory with the powerful Valence-Limited ...
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